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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRAK1
All Species:
13.03
Human Site:
S546
Identified Species:
31.85
UniProt:
P51617
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51617
NP_001020413.1
712
76537
S546
P
P
S
P
Q
E
N
S
Y
V
S
S
T
G
R
Chimpanzee
Pan troglodytes
XP_521332
850
89683
S687
P
P
S
P
Q
E
N
S
Y
V
S
S
T
G
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_549367
722
76996
Q542
H
H
G
P
P
S
P
Q
E
N
S
Y
V
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q62406
710
77251
S543
S
P
S
P
Q
E
N
S
Y
M
S
T
T
G
S
Rat
Rattus norvegicus
Q4QQS0
624
69218
A471
G
L
L
P
E
A
C
A
E
T
W
A
T
A
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508862
872
94244
S658
P
A
S
P
Q
E
N
S
Y
M
F
T
P
H
C
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_697688
686
76453
S512
E
P
L
R
S
D
S
S
S
I
D
S
L
S
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002312803
404
44281
A251
L
A
K
L
G
P
S
A
S
Q
S
H
V
T
T
Maize
Zea mays
NP_001132095
412
44547
G259
K
P
K
L
S
D
F
G
L
A
R
E
G
P
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q06548
410
45501
L257
E
Y
L
A
T
G
H
L
T
T
K
S
D
V
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
77.1
N.A.
83
N.A.
81
27.6
N.A.
49.4
N.A.
N.A.
36.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
78.9
N.A.
87.8
N.A.
85.2
44.9
N.A.
59
N.A.
N.A.
52.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
N.A.
13.3
N.A.
73.3
13.3
N.A.
53.3
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
N.A.
13.3
N.A.
86.6
33.3
N.A.
66.6
N.A.
N.A.
40
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.8
25.8
N.A.
22.8
N.A.
N.A.
Protein Similarity:
33
36.2
N.A.
35.3
N.A.
N.A.
P-Site Identity:
6.6
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
20
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
0
10
0
10
0
20
0
10
0
10
0
10
0
% A
% Cys:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
10
% C
% Asp:
0
0
0
0
0
20
0
0
0
0
10
0
10
0
0
% D
% Glu:
20
0
0
0
10
40
0
0
20
0
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
10
0
0
0
0
% F
% Gly:
10
0
10
0
10
10
0
10
0
0
0
0
10
30
0
% G
% His:
10
10
0
0
0
0
10
0
0
0
0
10
0
10
10
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
10
0
20
0
0
0
0
0
0
0
10
0
0
0
0
% K
% Leu:
10
10
30
20
0
0
0
10
10
0
0
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
20
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
40
0
0
10
0
0
0
0
0
% N
% Pro:
30
50
0
60
10
10
10
0
0
0
0
0
10
10
0
% P
% Gln:
0
0
0
0
40
0
0
10
0
10
0
0
0
0
0
% Q
% Arg:
0
0
0
10
0
0
0
0
0
0
10
0
0
0
10
% R
% Ser:
10
0
40
0
20
10
20
50
20
0
50
40
0
20
20
% S
% Thr:
0
0
0
0
10
0
0
0
10
20
0
20
40
10
20
% T
% Val:
0
0
0
0
0
0
0
0
0
20
0
0
20
10
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
0
40
0
0
10
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _